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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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J Bacteriol. 1990;172(11):6611-4.
Regulation of expression of the ftsA cell division gene by sequences in upstream genes.
Dewar SJ, Donachie WD.
(
2228979
)
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Deletion
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OCR30,31-3 (BK2-1 / AK1-1)
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
ftsA
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Related strains
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Strains Search
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Search strains by gene name:
ftsA
Search strains by all related name:
ftsA b0094 divA ECK0095 JW0092
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General information (Go to Linear View: )
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Gene Name
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ftsA
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Alternative name
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b0094,divA,ECK0095,JW0092
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Location, Length
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103,982 - 105,244
(
+
)
;
2.24
min
;
1263
(bp) ,
420
(aa)
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Product
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ATP-binding cell division protein involved in recruitment of FtsK to Z ring
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Operon Name
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mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
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Note
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ATP-binding cell division protein, septation process, complexes with FtsZ, associated with junctions of inner and outer membranes; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane
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Function
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phenotype; Cell division
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Gene Ontology
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GO:0007049
;
cell cycle ( ftsA )
GO:0008360
;
regulation of cell shape ( ftsA )
GO:0051301
;
cell division ( ftsA )
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PID
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1786282
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show details
)
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Entry name(Acc.no)
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FTSA_ECOLI
(
P06137
;
Q47229
)
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- Protein name
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Cell division protein ftsA.
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- Synonyms
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- Gene name
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OrderedLocusNames=b0094, c0112, z0104, ECs0098, SF0091, S0093;
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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ftsA
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
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Chain T, Ftsa
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Cell division protein ftsA
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PSI-BLAST
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Chaperone protein dnaK2
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nr
(database updated :
2007.02.20
)
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BLAST
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Cell division protein ftsA
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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ASN_GLYCOSYLATION
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
PROKAR_LIPOPROTEIN
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MMBR References
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J Bacteriol. 1987;169(5):1938-42.
Regulation of cell division in Escherichia coli K-12: probable interactions among proteins FtsQ, FtsA, and FtsZ.
Descoteaux A, Drapeau GR.
(
3032902
)
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J Bacteriol. 1996;178:7167-7172
FtsA is localized to the septum in an FtsZ-dependent manner.
Addinall, S. G., and J. Lutkenhaus.
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EMBO J. 1984;3:1181-1186
Inactivation of essential division genes ftsA, ftsZ, suppresses mutations at sfiB, a locus mediating division inhibition during the SOS response in E. coli.
Jones, C. A., and I. B. Holland.
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J Bacteriol. 1980;142(2):615-20.
Organization of genes in the ftsA-envA region of the Escherichia coli genetic map and identification of a new fts locus (ftsZ).
Lutkenhaus JF, Wolf-Watz H, Donachie WD.
(
6991482
)
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J Bacteriol. 1980;143(3):1281-8.
Determination of transcriptional units and gene products from the ftsA region of Escherichia coli.
Lutkenhaus JF, Wu HC.
(
6447690
)
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Proc Natl Acad Sci U S A. 1996;93:12998-13003
Colocalization of cell division proteins FtsZ and FtsA to cytoskeletal structures in living Escherichia coli cells by using green fluorescent protein.
Ma, X., D. W. Ehrhardt, and W. Margolin.
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J Bacteriol. 1985;163(2):615-22.
Cell shape and division in Escherichia coli: experiments with shape and division mutants.
Begg KJ, Donachie WD.
(
3894330
)
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J Bacteriol. 1984;160(2):546-55.
DNA sequence and transcriptional organization of essential cell division genes ftsQ and ftsA of Escherichia coli: evidence for overlapping transcriptional units.
Robinson AC, Kenan DJ, Hatfull GF, Sullivan NF, Spiegelberg R, Donachie WD.
(
6094474
)
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Res Microbiol. 1991;142(6):623-31.
Isolation and characterization of intragenic suppressors of an Escherichia coli ftsA mutation.
Robinson AC, Begg KJ, MacArthur E.
(
1961975
)
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J Bacteriol. 1984;158(3):1198-201.
Overlapping functional units in a cell division gene cluster in Escherichia coli.
Sullivan NF, Donachie WD.
(
6327635
)
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Bioessays. 1995;17(6):527-36.
Overview of controls in the Escherichia coli cell cycle.
Vinella D, D'Ari R.
(
7575494
)
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J Mol Biol. 1985;184(3):399-412.
Structure and expression of the cell division genes ftsQ, ftsA and ftsZ.
Yi QM, Rockenbach S, Ward JE Jr, Lutkenhaus J.
(
2995680
)
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EMBO J. 1990;9:3787-3794
Division genes in Escherichia coli are expressed coordinately to cell septum requirements by gearbox promoters.
Aldea, M., T. Garrido, J. Pla, and M. Vicente.
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Nucleic Acids Res. 1996;24:3065-3070
RNase E processing of essential cell division genes mRNA in Escherichia coli.
Cam, K., G. Rome, H. M. Krisch, and J. P. Bouche.
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| Sequences |
Amino acid
FASTA format
|
0001 MIKATDRKLV VGLEIGTAKV AALVGEVLPD GMVNIIGVGS CPSRGMDKGG VNDLESVVKC VQRAIDQAEL
0071 MADCQISSVY LALSGKHISC QNEIGMVPIS EEEVTQEDVE NVVHTAKSVR VRDEHRVLHV IPQEYAIDYQ
0141 EGIKNPVGLS GVRMQAKVHL ITCHNDMAKN IVKAVERCGL KVDQLIFAGL ASSYSVLTED ERELGVCVVD
0211 IGGGTMDIAV YTGGALRHTK VIPYAGNVVT SDIAYAFGTP PSDAEAIKVR HGCALGSIVG KDESVEVPSV
0281 GGRPPRSLQR QTLAEVIEPR YTELLNLVNE EILQLQEKLR QQGVKHHLAA GIVLTGGAAQ IEGLAACAQR
0351 VFHTQVRIGA PLNITGLTDY AQEPYYSTAV GLLHYGKESH LNGEAEVEKR VTASVGSWIK RLNSWLRKEF
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ACGTTGATTT GCGTTATGAC TCTGGAGCGG
-070 CAGTAGGCTG GGCGCCCTTG CCGCCAGAGG AATCTACTCA GCAACAAAAT CAGGCACAGG CAGAACAACA
0001 atgatcaagg cgacggacag aaaactggta gtaggactgg agattggtac cgcgaaggtt gccgctttag
0071 taggggaagt tctgcccgac ggtatggtca atatcattgg cgtgggcagc tgcccgtcgc gtggtatgga
0141 taaaggcggg gtgaacgacc tcgaatccgt ggtcaagtgc gtacaacgcg ccattgacca ggcagaattg
0211 atggcagatt gtcagatctc ttcggtatat ctggcgcttt ctggtaagca catcagctgc cagaatgaaa
0281 ttggtatggt gcctatttct gaagaagaag tgacgcaaga agatgtggaa aacgtcgtcc ataccgcgaa
0351 atcggtgcgt gtgcgcgatg agcatcgtgt gctgcatgtg atcccgcaag agtatgcgat tgactatcag
0421 gaagggatca agaatccggt aggactttcg ggcgtgcgga tgcaggcaaa agtgcacctg atcacatgtc
0491 acaacgatat ggcgaaaaac atcgtcaaag cggttgaacg ttgtgggctg aaagttgacc aactgatatt
0561 tgccggactg gcatcaagtt attcggtatt gacggaagat gaacgtgaac tgggtgtctg cgtcgtcgat
0631 atcggtggtg gtacaatgga tatcgccgtt tataccggtg gggcattgcg ccacactaag gtaattcctt
0701 atgctggcaa tgtcgtgacc agtgatatcg cttacgcctt tggcacgccg ccaagcgacg ccgaagcgat
0771 taaagttcgc cacggttgtg cgctgggttc catcgttgga aaagatgaga gcgtggaagt gccgagcgta
0841 ggtggtcgtc cgccacggag tctgcaacgt cagacactgg cagaggtgat cgagccgcgc tataccgagc
0911 tgctcaacct ggtcaacgaa gagatattgc agttgcagga aaagcttcgc caacaagggg ttaaacatca
0981 cctggcggca ggcattgtat taaccggtgg cgcagcgcag atcgaaggtc ttgcagcctg tgctcagcgc
1051 gtgtttcata cgcaagtgcg tatcggcgcg ccgctgaaca ttaccggttt aacggattat gctcaggagc
1121 cgtattattc gacggcggtg ggattgcttc actatgggaa agagtcacat cttaacggtg aagctgaagt
1191 agaaaaacgt gttacagcat cagttggctc gtggatcaag cgactcaata gttggctgcg aaaagagttt
1261 taaTTTTTAT GAGGCCGACG ATGATTACGG CCTCAGGCGA CAGGCACAAA TCGGAGAGAA ACTATGTTTG
1331 AACCAATGGA ACTTACCAAT GACGCGGTGA TTA
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