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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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J Bacteriol. 1999;181(9):2733-8.
The Escherichia coli homologue of yeast RER2, a key enzyme of dolichol synthesis, is essential for carrier lipid formation in bacterial cell wall synthesis.
Kato J, Fujisaki S, Nakajima K, Nishimura Y, Sato M, Nakano A.
(
10217761
)
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Deletion
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OCR33,35-4 (AK4-2 / BK5-2)
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
cdsA
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Related strains
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Strains Search
|
Search strains by gene name:
cdsA
Search strains by all related name:
cdsA b0175 ECK0174 geneA JW5810
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General information (Go to Linear View: )
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Gene Name
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cdsA
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Alternative name
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b0175,ECK0174,geneA,JW5810
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Location, Length
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195,677 - 196,534
(
+
)
;
4.22
min
;
858
(bp) ,
285
(aa)
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Product
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CDP-diglyceride synthase
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Operon Name
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cdsA
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Note
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CDP-diglyceride synthetase; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0008654 - phospholipid biosynthetic process
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Function
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enzyme; Fatty acid and phosphatidic acid biosynthesis
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Gene Ontology
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GO:0004605
;
phosphatidate cytidylyltransferase activity ( cdsA )
GO:0005886
;
plasma membrane ( cdsA )
GO:0008654
;
phospholipid biosynthetic process ( cdsA )
GO:0016020
;
membrane ( cdsA )
GO:0016021
;
integral to membrane ( cdsA )
GO:0016740
;
transferase activity ( cdsA )
GO:0016779
;
nucleotidyltransferase activity ( cdsA )
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PID
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87081696
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EC number
(KEGG Pathway)
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2.7.7.41
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
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CDSA_ECOLI
(
P06466
)
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- Protein name
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Phosphatidate cytidylyltransferase
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- Synonyms
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EC 2.7.7.41, CDP-diglyceride synthetase, CDP-diglyceride pyrophosphorylase, CDP-diacylglycerol synthase, CDS, CTP:phosphatidate cytidylyltransferase, CDP-DAG synthase, CDP-DG synthetase
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- Gene name
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OrderedLocusNames=b0175, z0186, ECs0177, SF0165, S0168;
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MMBR References
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J Biol Chem. 1980;255:1623-1629
Phosphatidic acid accumulation in the membranes of Escherichia coli mutants defective in CDP-digylceride synthetase.
Ganong, B. R., J. M. Leonard, and C. R. H. Raetz.
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J Biol Chem. 1985;260:12078-12083
Molecular cloning and sequencing of the gene for CDP-diglyceride synthetase of Escherichia coli.
Icho, T., C. P. Sparrow, and C. R. H. Raetz.
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| Sequences |
Amino acid
FASTA format
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0001 MLKYRLISAF VLIPVVIAAL FLLPPVGFAI VTLVVCMLAA WEWGQLSGFT TRSQRVWLAV LCGLLLALML
0071 FLLPEYHRNI HQPLVEISLW ASLGWWIVAL LLVLFYPGSA AIWRNSKTLR LIFGVLTIVP FFWGMLALRA
0141 WHYDENHYSG AIWLLYVMIL VWGADSGAYM FGKLFGKHKL APKVSPGKTW QGFIGGLATA AVISWGYGMW
0211 ANLDVAPVTL LICSIVAALA SVLGDLTESM FKREAGIKDS GHLIPGHGGI LDRIDSLTAA VPVFACLLLL
0281 VFRTL
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TGAACAAGAC TTTGAAGGGG CGTTAAATGC
-070 CTTTGCTAAT CGAGAGCGTC GTTTCGGCGG CACCGAGCCC GGTGATGAAA CAGCCTGATG GGGGTCGCTT
0001 ttgctgaagt atcgcctgat atctgctttt gtgttaatac ccgtcgtcat cgcggcgttg tttctgttgc
0071 cgccggtggg gttcgccatt gtaacgctgg tggtctgcat gctggcagcg tgggaatggg gacagcttag
0141 cggttttacc actcgttcgc agcgagtatg gttggcggtg ttatgcgggt tattgttggc gctgatgctt
0211 tttctgttgc cggaatatca ccgaaatatt catcaaccgc tggttgaaat ctcactttgg gcttcgctgg
0281 gttggtggat tgtcgcgcta ttgctggtgc tgttttaccc aggttccgca gcaatctggc gtaactctaa
0351 aacattgcgc cttatttttg gcgtgctaac cattgttccc ttcttctggg gcatgctggc gttacgggcc
0421 tggcactatg acgagaatca ttacagtggc gcaatatggc tgctctatgt catgatcctg gtatggggcg
0491 ctgactccgg cgcatatatg tttggcaaat tgtttggtaa acataagctg gcaccgaagg tttctccggg
0561 taaaacctgg caaggcttta tcggtggact cgctactgca gcggtaatct catggggtta tggcatgtgg
0631 gcgaatctcg acgtcgctcc cgtcacctta ctcatttgct ctattgtcgc agcgttagcc tcagtgctcg
0701 gcgatctgac cgagagtatg tttaagcgtg aagcaggaat taaggacagc ggtcatttaa ttccaggaca
0771 cggtggtatt ttagatcgta ttgatagcct gacggctgcg gtaccggtct ttgcttgctt gttgttactg
0841 gtattcagga cgctttaaCG GAAGGTAATA TGCTGAGTTT TCTCTGGGAT TTGGCTTCGT TCATCGTTGC
0911 ACTGGGTGTA CTTATCACCG TGCATGAATT TGGTCATTTC TGGGTTGC
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